Neuropathology is a specialised area within cellular pathology that uses both H&E and special stains to interpret neuropathology specimens. H&E is the primary stain used for all samples, providing essential morphological details for the neuropathologist. Special stains are critical in neuropathology, especially in non-tumour cases, and their use varies based on the sample type and disease category. Techniques range from traditional tinctorial methods to histochemical and immunocytochemical approaches, depending on the disease and testing organisation.

Rationale

The Neuropathology scheme evaluates specialised methods by distributing known target material on a rotational basis. Each participant receives 2 unstained sections (A & B) to assess the sensitivity and specificity of their techniques. Stain A uses a routine Cellular Pathology method, while stain B uses a specialist Neuropathological method, which may include immunohistochemical techniques if preferred by the organisation.

Submission

1  of each of the 2 provided A and B slides is stained using the specified specialist stains, as outlined in the delivery letter.

Results Reporting

• Individualised Results Report
• Participation Certificate
• Annual Report